Effects of chlorpromazine and estradiol benzoate on prolactin secretion in gonadectomized male and female rats.
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Effects of chlorpromazine and estradiol benzoate on prolactin secretion in gonadectomized male and female rats.
The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in th...
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متن کاملThe Effects of Chlorpromazine on Reproductive System and Function in Female Rats
Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and alteration of ovarian source hormones. MaterialsAndMethods In this experimental study, animals were divided into four groups, ...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1979
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.26.419